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I was reviewing some new studies on the use of insulin this past week and every study seemed to use HOMA values. Homeostatic model assessment (HOMA) was first used in 1985 and was derived mathematically by looking at the interaction between beta-cell function and insulin resistance of normoglycemic patients. Alexander Julian, PharmD Candidate, UF College of Pharmacy, put everything in perspective for me and if you Click Here you can see what I learned from him.HOMA: Often Mentioned, Rarely DefinedAlexander Julian Doctor of Pharmacy CandidateUniversity of Florida College of PharmacyHomeostatic model assessment (HOMA) is commonly cited in the literature but many clinicians and health professionals are unfamiliar with what it is, what it is used for, and most importantly, why it is used. A pubmed search of the term “HOMA” results in over 3600 hits; many of these are studies that use HOMA to analyze their data and draw conclusions. Simply put, HOMA is a method to quantify insulin resistance and beta-cell function. Originally described in 1985, the original model (HOMA1) was derived mathematically by looking at the interaction between beta-cell function (HOMA1-%B) in response to glucose concentrations, and insulin resistance (HOMA1-IR) in which insulin has diminished suppressive effect on hepatic glucose production. Because a feedback loop between the liver and beta-cells balances insulin secretion and hepatic glucose output, theoretically, it makes it possible to compute steady-state insulin and glucose concentrations.
The original model was calibrated to give normal beta-cell function of 100% and normal insulin resistance of 1. Higher insulin resistance is characterized by higher steady state insulin levels and reduced beta-cell function characterized by a decreased compensation to increase glucose levels.
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